Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children.

ABSTRACT:

Background

Intensive malaria control may have additional benefits beyond reducing the incidence of symptomatic malaria. We compared antibiotic treatment of children before and after the implementation of highly effective malaria control interventions in Tororo, a historically high transmission area of Uganda.

Methods

Two successive cohorts of children, aged 0.5 to 10 years, were followed from September 2011 to October 2019 in a dedicated study clinic. Universal distribution of long-lasting insecticidal nets was conducted in 2013 and 2017. Sustained indoor residual spraying of insecticide (IRS) was initiated in December 2014. Generalized linear mixed-effects models were used to compare the incidence of antimalarial and antibiotic treatments before and after vector control mea

SUBMITTER: Krezanoski PJ 

PROVIDER: S-EPMC8630830 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature