Transcriptome analysis of lncRNA expression patterns in human congenital lung malformations.

ABSTRACT:

Objectives

To explore the long non-coding RNA (lncRNA) expression pattern of congenital lung malformations on a genome-wide scale and investigate their potential biological function in four subtypes of congenital lung malformations.

Methods

We obtained both lesions and normal lung control tissues from the patients diagnosed with CPAM-I, CPAM-II, ILS, and ILS-CPAM, and underwent lobectomy (i.e., surgical removal of the whole lobe which contains the localized lesion as well as normal lung tissue). Then, we performed lncRNA transcriptome profiling in these tissues by RNA sequencing (RNA-seq). A comprehensive bioinformatics analysis was conducted to characterize the expression profiles and relevant biological functions and for multiple comparisons of lncRNA expression in the dif

SUBMITTER: Yang W 

PROVIDER: S-EPMC8630864 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature