Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome: A secondary analysis of the Practice of VENTilation in COVID-19 study.

ABSTRACT:

Background

There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19).

Objective

To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy regarding the number of ventilator-free days (VFDs).

Design

Multicentre observational study conducted from 1 March to 1 June 2020.

Setting and patients

Twenty-two ICUs in The Netherlands and 933 invasively ventilated COVID-19 ARDS patients.

Interventions

Patients were categorised retrospectively as having received invasive ventilation with higher (n=259) or lower PEEP (n=674), based on the high and low PEEP/FiO2 tables of the ARDS Network, and using ventilator

SUBMITTER: Valk CMA 

PROVIDER: S-EPMC8630930 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature