Androgen abuse and the brain.

ABSTRACT:

Purpose of review

The purpose of this review is to examine the recent evidence regarding the effects of exogenous androgens on the brain. Understanding these effects is of high importance, as the consequences of androgens on the reproductive and endocrine system are well documented, while fewer studies have focused on the neural and cerebral consequences of androgen use.

Recent findings

Supraphysiological doses of androgens have been shown to contribute to neurodegeneration, decreased brain-derived neurotrophic factor, increased inflammation and decreased neuronal density in animal studies, which may correspond to changes in mood, cognition and aggression. Findings from human studies suggest that similar behavioural and cognitive deficits may occur as a result of prolonged u

SUBMITTER: Scarth M 

PROVIDER: S-EPMC8631164 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature