The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.

ABSTRACT:

Background

Bipolar disorder (BD) is a severe mental disorder, characterized by prominent mood swings and emotion regulation (ER) deficits. The uncinate fasciculus (UF), a white matter tract connecting the amygdala and the ventral prefrontal cortex, has been implicated in ER. Aberrancies in UF microstructure may be an endophenotype associated with increased risk for BD. However, studies in individuals with BD and their first-degree relatives (REL) have yielded inconsistent findings. This meta-analysis takes a region-of-interest approach to consolidate the available evidence and elucidate the role of the UF in the risk-architecture of BD.

Methods

Using web-based search engines, we identified diffusion tensor imaging (DTI) studies focusing on the left and right UF and conducted

SUBMITTER: Xu E 

PROVIDER: S-EPMC8631233 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature