A High-Content Microscopy Screening Identifies New Genes Involved in Cell Width Control in Bacillus subtilis.

ABSTRACT: How cells control their shape and size is a fundamental question of biology. In most bacteria, cell shape is imposed by the peptidoglycan (PG) polymeric meshwork that surrounds the cell. Thus, bacterial cell morphogenesis results from the coordinated action of the proteins assembling and degrading the PG shell. Remarkably, during steady-state growth, most bacteria maintain a defined shape along generations, suggesting that error-proof mechanisms tightly control the process. In the rod-shaped model for the Gram-positive bacterium Bacillus subtilis, the average cell length varies as a function of the growth rate, but the cell diameter remains constant throughout the cell cycle and across growth conditions. Here, in an attempt to shed light on the cellular circuits controlling bacterial cell

SUBMITTER: Juillot D 

PROVIDER: S-EPMC8631317 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature