Data harmonization and data pooling from cohort studies: a practical approach for data management.

ABSTRACT: Data pooling from pre-existing datasets can be useful to increase study sample size and statistical power in order to answer a research question. However, individual datasets may contain variables that measure the same construct differently, posing challenges for data pooling. Variable harmonization, an approach that can generate comparable datasets from heterogeneous sources, can address this issue in some circumstances. As an illustrative example, this paper describes the data harmonization strategies that helped generate comparable datasets across two Canadian pregnancy cohort studies: All Our Families; and the Alberta Pregnancy Outcomes and Nutrition. Variables were harmonized considering multiple features across the datasets: the construct measured; question asked/response options; th

SUBMITTER: Adhikari K 

PROVIDER: S-EPMC8631396 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature