Basic Predictive Risk Factors for Cytokine Storms in COVID-19 Patients.

ABSTRACT:

Objective

A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused by overproduction of proinflammatory cytokines, known as "a cytokine storm" (CS), strongly associated with a severe course of disease. The aim of this study is to identify prognostic biomarkers for CS development in COVID-19 patients and integrate them into a prognostic score for CS-associated risk applicable to routine clinical practice.

Materials and methods

The authors performed a review of 458 medical records from COVID-19 patients (241 men and 217 women aged 60.0 ± 10.0) who received treatment in the St. Petersburg State Budgetary Institution of Healthcare City Hospital 40 (City

SUBMITTER: Shcherbak SG 

PROVIDER: S-EPMC8631447 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature