Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection.

ABSTRACT: Systemic duress, such as that elicited by sepsis, burns, or trauma, predisposes patients to secondary pneumonia, demanding better understanding of host pathways influencing this deleterious connection. These pre-existing circumstances are capable of triggering the hepatic acute-phase response (APR), which we previously demonstrated is essential for limiting susceptibility to secondary lung infections. To identify potential mechanisms underlying protection afforded by the lung-liver axis, our studies aimed to evaluate liver-dependent lung reprogramming when a systemic inflammatory challenge precedes pneumonia. Wild-type mice and APR-deficient littermate mice with hepatocyte-specific deletion of STAT3 (hepSTAT3^-/-), a transcription factor necessary for full APR initiation, were ch

SUBMITTER: Odom CV 

PROVIDER: S-EPMC8631467 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature