Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression.

ABSTRACT: Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show significant heritability, suggesting shared pathophysiological mechanisms. Non-homeostatic function of ion channels and neuroinflammation may be common mechanisms underlying both disorders: The excitation-inhibition balance of microcircuits and their modulation by monoaminergic systems, which depend on the expression and function of membrane located K⁺, Na⁺, and Ca⁺² channels, have been reported to be disturbed in both depression and migraine. Ion channels and energy supply to synapses not only change excitability of neurons but can also mediate the induction and maintenance of inflammatory signaling implic

SUBMITTER: Eren-Kocak E 

PROVIDER: S-EPMC8631474 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature