High Frequencies of Functional Virus-Specific CD4⁺ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders.

ABSTRACT: Olfactory and taste disorders (OTD) are commonly found as presenting symptoms of SARS-CoV-2 infection in patients with clinically mild COVID-19. Virus-specific T cells are thought to play an important role in the clearance of SARS-CoV-2; therefore the study of T cell specific immune responses in patients with mild symptoms may help to understand their possible role in protection from severe disease. We evaluated SARS-CoV-2-specific T cell responses to four different peptide megapools covering all SARS-CoV-2 proteins during the acute phase of the disease in 33 individuals with mild or no other symptom beside OTD and in 22 age-matched patients with severe infection. A control group of 15 outpatients with OTD and consistently negative nasopharyngeal SARS-CoV-2 RNA swabs and virus-specific IgG

SUBMITTER: Mele D 

PROVIDER: S-EPMC8631501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature