Deciphering the Epidemiological Characteristics and Molecular Features of bla _KPC-2- or bla _NDM-1-Positive Klebsiella pneumoniae Isolates in a Newly Established Hospital.

ABSTRACT: The emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) was regarded as an emerging threat in clinical settings. Here, we investigated the prevalence of CRKP strains among inpatients in a new hospital over 1 year since its inception with various techniques, and carried out a WGS-based phylogenetic study to dissect the genomic background of these isolates. The genomes of three representative bla _NDM-1-positive strains and the plasmids of four bla _KPC-2-positive strains were selected for Nanopore long-read sequencing to resolve the complicated MDR structures. Thirty-five CRKP strains were identified from 193 K. pneumoniae isolates, among which 30 strains (85.7%) harbored bla _KPC-2, whereas the rem

SUBMITTER: Chen R 

PROVIDER: S-EPMC8631570 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature