Deciphering the molecular mechanism of the cancer formation by chromosome structural dynamics.

ABSTRACT: Cancer reflects the dysregulation of the underlying gene network, which is strongly related to the 3D genome organization. Numerous efforts have been spent on experimental characterizations of the structural alterations in cancer genomes. However, there is still a lack of genomic structural-level understanding of the temporal dynamics for cancer initiation and progression. Here, we use a landscape-switching model to investigate the chromosome structural transition during the cancerization and reversion processes. We find that the chromosome undergoes a non-monotonic structural shape-changing pathway with initial expansion followed by compaction during both of these processes. Furthermore, our analysis reveals that the chromosome with a more expanding structure than those at both the normal

SUBMITTER: Chu X 

PROVIDER: S-EPMC8631624 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature