Evoked potentials as biomarkers of hereditary spastic paraplegias: A case-control study.

ABSTRACT:

Introduction

The Hereditary Spastic Paraplegias (HSP) are a group of genetic diseases that lead to slow deterioration of locomotion. Clinical scales seem to have low sensitivity in detecting disease progression, making the search for additional biomarkers a paramount task. This study aims to evaluate the role of evoked potentials (EPs) as disease biomarkers of HSPs.

Methods

A single center cross-sectional case-control study was performed, in which 18 individuals with genetic diagnosis of HSP and 21 healthy controls were evaluated. Motor evoked potentials (MEP) obtained with transcranial magnetic stimulation and somatosensory evoked potentials (SSEP) were performed in lower (LL) and upper limbs (UL).

Results

Central motor conduction time in lower limbs (CMCT-LL) was pr

SUBMITTER: Brighente SF 

PROVIDER: S-EPMC8631666 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature