Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection.

ABSTRACT: Theoretically, with a high enough drug dosage, cancer cells could be eliminated. However, the dosages that can be administered are limited by the therapeutic efficacy and side effects of the given drug. Herein, a nanomedicine integrating chemotherapeutic sensitization and protection was developed to relieve the limitation of administration dosage and to improve the efficacy of chemotherapy. The nanomedicine was endowed with the function of synergistically controlled release of CO and drugs under near-infrared (NIR) light irradiation. CO photo-induced release system (COPIRS) was synthesized by constructing an electron excitation-electron transfer group-electron-induced CO release structure and was used as the hydrophobic part, and then hydrophilic polymer (polyethylene glycol; PEG) was intr

SUBMITTER: Liu S 

PROVIDER: S-EPMC8631718 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature