Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape.

ABSTRACT: Realistic mappings of genes to morphology are inherently multivariate on both sides of the equation. The importance of coordinated gene effects on morphological phenotypes is clear from the intertwining of gene actions in signaling pathways, gene regulatory networks, and developmental processes underlying the development of shape and size. Yet, current approaches tend to focus on identifying and localizing the effects of individual genes and rarely leverage the information content of high-dimensional phenotypes. Here, we explicitly model the joint effects of biologically coherent collections of genes on a multivariate trait - craniofacial shape - in a sample of n = 1145 mice from the Diversity Outbred (DO) experimental line. We use biological process Gene Ontology (GO) annotations to selec

SUBMITTER: Aponte JD 

PROVIDER: S-EPMC8631940 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature