Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics.

ABSTRACT: The prefrontal cortex (PFC) is thought to orchestrate cognitive dynamics. However, in tests of bistable visual perception, no direct evidence supporting such presumable causal roles of the PFC has been reported except for a recent work. Here, using a novel brain-state-dependent neural stimulation system, we identified causal effects on percept dynamics in three PFC activities-right frontal eye fields, dorsolateral PFC (DLPFC), and inferior frontal cortex (IFC). The causality is behaviourally detectable only when we track brain state dynamics and modulate the PFC activity in brain-state-/state-history-dependent manners. The behavioural effects are underpinned by transient neural changes in the brain state dynamics, and such neural effects are quantitatively explainable by structural transfo

SUBMITTER: Watanabe T 

PROVIDER: S-EPMC8631941 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature