Different Risks of Mortality and Longitudinal Transition Trajectories in New Potential Subtypes of the Preserved Ratio Impaired Spirometry: Evidence From the English Longitudinal Study of Aging.

ABSTRACT: Background: Preserved ratio impaired spirometry (PRISm), characterized by the decreased forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) with a preserved FEV₁/FVC ratio, is highly prevalent and heterogeneous. We aimed to identify the subtypes of PRISm and examine their differences in clinical characteristics, long-term mortality risks, and longitudinal transition trajectories. Methods: A total of 6,616 eligible subjects were included from the English longitudinal study of aging. Two subtypes of the PRISm were identified as mild PRISm (either of FEV₁ and FVC <80% predicted value, FEV₁/FVC ≥0.7) and severe PRISm (both FEV₁ and FVC <80% predicted values, FEV₁/FVC ≥0.7). Normal spirometry was

SUBMITTER: He D 

PROVIDER: S-EPMC8631955 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature