Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis.

ABSTRACT: Streptococcus suis is an emerging zoonotic pathogen. Over 100 putative virulence factors have been described, but it is unclear to what extent these virulence factors could contribute to zoonotic potential of S. suis. We identified all S. suis virulence factors studied in experimental models of human origin in a systematic review and assessed their contribution to zoonotic potential in a subsequent genomic meta-analysis. PubMed and Scopus were searched for English-language articles that studied S. suis virulence published until 31 March 2021. Articles that analyzed a virulence factor by knockout mutation, purified protein, and/or recombinant protein in a model of human origin, were included. Data on virulence factor, strain characteristics, used human models and

SUBMITTER: Roodsant TJ 

PROVIDER: S-EPMC8632099 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature