M6A-BiNP: predicting N⁶-methyladenosine sites based on bidirectional position-specific propensities of polynucleotides and pointwise joint mutual information.

ABSTRACT: N⁶-methyladenosine (m⁶A) plays an important role in various biological processes. Identifying m⁶A site is a key step in exploring its biological functions. One of the biggest challenges in identifying m⁶A sites is how to extract features comprising rich categorical information to distinguish m⁶A and non-m⁶A sites. To address this challenge, we propose bidirectional dinucleotide and trinucleotide position-specific propensities, respectively, in this paper. Based on this, we propose two feature-encoding algorithms: Position-Specific Propensities and Pointwise Mutual Information (PSP-PMI) and Position-Specific Propensities and Pointwise Joint Mutual Information (PSP-PJMI). PSP-PMI is based on the bidirectional dinucleotide prop

SUBMITTER: Wang M 

PROVIDER: S-EPMC8632114 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature