Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom.

ABSTRACT: Genome architecture has proven to be critical in determining gene regulation across almost all domains of life. While many of the key components and mechanisms of eukaryotic genome organization have been described, the interplay between bacterial DNA organization and gene regulation is only now being fully appreciated. An increasing pool of evidence has demonstrated that the bacterial chromosome can reasonably be thought of as chromatin, and that bacterial chromosomes contain transcriptionally silent and transcriptionally active regions analogous to heterochromatin and euchromatin, respectively. The roles played by histones in eukaryotic systems appear to be shared across a range of nucleoid-associated proteins (NAPs) in bacteria, which function to compact, structure, and regulate large po

SUBMITTER: Amemiya HM 

PROVIDER: S-EPMC8632127 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature