Dataset Information

SARS-CoV-2 Sequence Analysis during COVID-19 Case Surge, Liberia, 2021.

ABSTRACT: In June 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases surged in Liberia. SARS-CoV-2 sequences from patients hospitalized during March-July 2021 revealed the Delta variant was in Liberia in early March and was dominant in June, irrespective of geography. Mutations and deletions suggest multiple SARS-CoV-2 Delta variant introductions.

SUBMITTER: Shobayo B

PROVIDER: S-EPMC8632187 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

SARS-CoV-2 Sequence Analysis during COVID-19 Case Surge, Liberia, 2021.

Shobayo Bode B Mishra Mitali M Sameroff Stephen S Petrosov Alexandra A Ng James J Gokden Alper A MaCauley Jane J Jain Komal K Renken Courtney C Duworko James Tanu JT Badio Moses M Jallah Wilhemina W Hensley Lisa L Briese Thomas T Lipkin W Ian WI Mishra Nischay N

Emerging infectious diseases 20211028 12

In June 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases surged in Liberia. SARS-CoV-2 sequences from patients hospitalized during March-July 2021 revealed the Delta variant was in Liberia in early March and was dominant in June, irrespective of geography. Mutations and deletions suggest multiple SARS-CoV-2 Delta variant introductions. ...[more]

PMID: 34708683

Similar Datasets

Project description:BackgroundStudies of mRNA and vector-based vaccines used in different countries report acceptable levels of effectiveness against SARS-CoV-2 infection caused by the Delta variants of SARS-CoV-2. No studies estimated vaccine effectiveness (VE) of Gam-COVID-Vac and other vaccines used in Russia against symptomatic infection with Delta variant. In this population-based case-control study, we aimed to estimate the effectiveness of the Russian COVID-19 vaccines against symptomatic SARS-CoV-2 during the recent outbreak caused by the Delta VOC in October 2021 in St. Petersburg, Russia.MethodsCases were symptomatic patients with confirmed SARS-CoV-2 (using polymerase chain reaction (PCR) test) referred to low-dose computed tomography (LDCT) triage in two outpatient centres between October 6 and 14, 2021 during the Delta variant outbreak. We recruited the controls during the representative survey of the seroprevalence study conducted during the same period in St. Petersburg using random digit dialling. In the primary analysis, we used logistic regression models to estimate the adjusted (age, sex, and history of confirmed COVID-19) VE against symptomatic SARS-CoV-2 resulted in a referral to triage centre for three vaccines used in Russia: Gam-COVID-Vac, EpiVacCorona, and CoviVac.ResultsWe included 1,254 cases and 2,747 controls recruited between the 6th and 14th of October in the final analysis. VE was 56% (95% CI: 48 to 63) for Gam-COVID-Vac (Sputnik V), 49% (95% CI: 29 to 63) for 1-dose Gam-COVID-Vac (Sputnik V) or Sputnik Light, -58% (95% CI: -225 to 23) for EpiVacCorona and 40% (95% CI: 3 to 63) for CoviVac. Without adjustment for the history of confirmed COVID-19 VE for all vaccines was lower, except for one-dose Gam-COVID-Vac (Sputnik Light). The adjusted VE was slightly lower in women - 51% (95% CI: 39 to 60) than men - 65% (95% CI: 5 to 73).ConclusionsOur preliminary results show that in contrast to other Russian vaccines, Gam-COVID-Vac is effective against symptomatic SARS-CoV-2 infection caused by Delta VOC. Effectiveness is likely higher than the estimated 56% due to bias arising from high prevalence of the past COVID-19 in St. Petersburg.

Dataset Information

SARS-CoV-2 Sequence Analysis during COVID-19 Case Surge, Liberia, 2021.

Publications

SARS-CoV-2 Sequence Analysis during COVID-19 Case Surge, Liberia, 2021.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets