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Targeting the immune microenvironment during immunotherapy for solid tumors.

ABSTRACT: JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies. We stress the importance of fully understanding how JAK/STAT modifies the immune response before implementing clinical trials combining JAK/STAT inhibitors with immunotherapy.

SUBMITTER: Sabaawy A 

PROVIDER: S-EPMC8632277 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Targeting the immune microenvironment during immunotherapy for solid tumors.

Sabaawy Aiman A   Zeeshan Saman S  

Molecular & cellular oncology 20211027 5

JAK/STAT signaling is a central hub in cancer development, progression, immunosurveillance and response to immunotherapy. We discuss recent advances in the role of the JAK/STAT pathway in immunotherapies. We stress the importance of fully understanding how JAK/STAT modifies the immune response before implementing clinical trials combining JAK/STAT inhibitors with immunotherapy. ...[more]

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