Intestinal microbial communities and Holdemanella isolated from HIV+/- men who have sex with men increase frequencies of lamina propria CCR5⁺ CD4⁺ T cells.

ABSTRACT: Men who have sex with men (MSM), regardless of HIV infection status, have an intestinal microbiome that is compositionally distinct from men who have sex with women (MSW) and women. We recently showed HIV-negative MSM have elevated levels of intestinal CD4⁺ T cells expressing CCR5, a critical co-receptor for HIV. Whether elevated expression of CCR5 is driven by the altered gut microbiome composition in MSM has not been explored. Here we used in vitro stimulation of gut Lamina Propria Mononuclear Cells (LPMCs) with whole intact microbial cells isolated from stool to demonstrate that fecal bacterial communities (FBCs) from HIV-positive/negative MSM induced higher frequencies of CCR5⁺ CD4⁺ T cells compared to FBCs from HIV-negative MSW and women. To ide

SUBMITTER: Yamada E 

PROVIDER: S-EPMC8632320 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature