Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile.

ABSTRACT: Mitochondria are essential organelles that provide energy for mammalian cells and participate in multiple functions, such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared with the mitochondria in somatic cells, oocyte mitochondria have an additional level of importance since they are required for germ cell maturation, dysfunction in which can lead to severe inherited disorders. Thus, a systematic proteomic profile of oocyte mitochondria is urgently needed to support the basic and clinical research, but the acquisition of such a profile has been hindered by the rarity of oocyte samples and technical challenges associated with capturing mitochondrial proteins from live oocytes. Here, in this work, using proximity labeling proteomics, we established a mi

SUBMITTER: Zhang N 

PROVIDER: S-EPMC8632880 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature