Anti-inflammatory effect of gold nanoparticles supported on metal oxides.

ABSTRACT: Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO₂, Au/ZrO₂ and Au/CeO₂ on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nat

SUBMITTER: Fujita T 

PROVIDER: S-EPMC8632916 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature