Placental extracellular vesicles-associated microRNA-519c mediates endotoxin adaptation in pregnancy.

ABSTRACT:

Background

Pregnancy represents a unique challenge for the maternal-fetal immune interface, requiring a balance between immunosuppression, which is essential for the maintenance of a semiallogeneic fetus, and proinflammatory host defense to protect the maternal-fetal interface from invading organisms. Adaptation to repeated inflammatory stimuli (endotoxin tolerance) may be critical in preventing inflammation-induced preterm birth caused by exaggerated maternal inflammatory responses to mild or moderate infections that are common during pregnancy. However, the exact mechanisms contributing to the maintenance of tolerance to repeated infections are not completely understood. MicroRNAs play important roles in pregnancy with several microRNAs implicated in gestational tissue function a

SUBMITTER: Tiozzo C 

PROVIDER: S-EPMC8633060 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature