Sweeps in time: leveraging the joint distribution of branch lengths.

ABSTRACT: Current methods of identifying positively selected regions in the genome are limited in two key ways: the underlying models cannot account for the timing of adaptive events and the comparison between models of selective sweeps and sequence data is generally made via simple summaries of genetic diversity. Here, we develop a tractable method of describing the effect of positive selection on the genealogical histories in the surrounding genome, explicitly modeling both the timing and context of an adaptive event. In addition, our framework allows us to go beyond analyzing polymorphism data via the site frequency spectrum or summaries thereof and instead leverage information contained in patterns of linked variants. Tests on both simulations and a human data example, as well as a comparison to

SUBMITTER: Bisschop G 

PROVIDER: S-EPMC8633083 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature