The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review.

ABSTRACT:

Background

Exogenous sex steroids within hormonal contraception and menopausal hormone therapy (MHT) have been used for family planning and management of menopausal symptoms, without consideration of their effects on the vaginal microbiota. This is largely because their use predates our understanding of the importance of the vaginal microbiome on human health. We conducted a systematic review (PROSPERO: CRD42018107730) to determine the influence of exogenous sex steroids, stratified by oestrogen-containing or progestin-only types of contraception, and MHT on the vaginal microbiome, as measured by molecular methods.

Methods

Embase, PubMed and Medline were searched for relevant literature published through to December 1st 2020. Eligible studies reported on the effect of specif

SUBMITTER: Ratten LK 

PROVIDER: S-EPMC8633117 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature