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Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma.


ABSTRACT: The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

SUBMITTER: Ricci C 

PROVIDER: S-EPMC8633150 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma.

Ricci Costantino C   Chiarucci Federico F   Ambrosi Francesca F   Balbi Tiziana T   Corti Barbara B   Piccin Ottavio O   Pasquini Ernesto E   Foschini Maria Pia MP  

Head and neck pathology 20210216 4


The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentia  ...[more]

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