Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens.

ABSTRACT: The tumor microenvironment (TME), including infiltrated immune cells, is known to play an important role in tumor growth; however, the mechanisms underlying tumor immunogenicity have not been fully elucidated. Here, we discovered an unexpected role for the transcription factor SIX1 in regulating the tumor immune microenvironment. Based on analyses of patient datasets, we found that SIX1 was upregulated in human tumor tissues and that its expression levels were negatively correlated with immune cell infiltration in the TME and the overall survival rates of cancer patients. Deletion of Six1 in cancer cells significantly reduced tumor growth in an immune-dependent manner with enhanced antitumor immunity in the TME. Mechanistically, SIX1 was required for the expression of multiple collagen gen

SUBMITTER: Liu W 

PROVIDER: S-EPMC8633173 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature