Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer.

ABSTRACT:

Background

Although skeletal muscle index (SMI) and radiodensity (SMD) are well-known prognostic factors, the clinical impact of the integrated measure, known as skeletal muscle gauge (SMG), has been limited in patients with colorectal cancer (CRC).

Patients and methods

A total of 727 and 268 patients with CRC at two tertiary centers were included and allocated into the training and test sets, respectively. Preoperative slice computed tomography images of the third lumbar area were evaluated for SMI and SMD. SMG was calculated as SMI × SMD and expressed as an arbitrary unit (AU). The optimal cutoff SMG value was determined to maximize the overall survival (OS) difference between the groups with respect to sex in the training set. The multivariate Cox proportional hazard mode

SUBMITTER: Park IK 

PROVIDER: S-EPMC8633260 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature