Ontology highlight
ABSTRACT:
SUBMITTER: Sahu A
PROVIDER: S-EPMC8633337 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Sahu Aditi A Oh Yuna Y Peterson Gary G Cordova Miguel M Navarrete-Dechent Cristian C Gill Melissa M Alessi-Fox Christi C Gonzalez Salvador S Phillips William W Wilson Steven S Afzalneia Reza R Rose Raven R Mohsen Abu-Akeel AA Bello Danielle D Marghoob Ashfaq A Rossi Anthony A Wolchok Jedd D JD Merghoub Taha T Rotemberg Veronica V Jason Chen Chih-Shan CS Rajadhyaksha Milind M
Scientific reports 20211130 1
Conventional tissue sampling can lead to misdiagnoses and repeated biopsies. Additionally, tissue processed for histopathology suffers from poor nucleic acid quality and/or quantity for downstream molecular profiling. Targeted micro-sampling of tissue can ensure accurate diagnosis and molecular profiling in the presence of spatial heterogeneity, especially in tumors, and facilitate acquisition of fresh tissue for molecular analysis. In this study, we explored the feasibility of performing 1-2 mm ...[more]