Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study.

ABSTRACT:

Background

Pediatric mild traumatic brain injury (mTBI) affects millions of children annually. Diffusion tensor imaging (DTI) is sensitive to axonal injuries and white matter microstructure and has been used to characterize the brain changes associated with mild traumatic brain injury (mTBI). Neurite orientation dispersion and density imaging (NODDI) is a diffusion model that can provide additional insight beyond traditional DTI metrics, but has not been examined in pediatric mTBI. The goal of this study was to employ DTI and NODDI to gain added insight into white matter alterations in children with mTBI compared to children with mild orthopedic injury (OI).

Methods

Children (mTBI n = 320, OI n = 176) aged 8-16.99 years (12.39 ± 2.32 years) were recruited from emergency depa

SUBMITTER: Shukla A 

PROVIDER: S-EPMC8633364 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature