Mapping pleiotropic loci using a fast-sequential testing algorithm.

ABSTRACT: Pleiotropy (i.e., genes with effects on multiple traits) leads to genetic correlations between traits and contributes to the development of many syndromes. Identifying variants with pleiotropic effects on multiple health-related traits can improve the biological understanding of gene action and disease etiology, and can help to advance disease-risk prediction. Sequential testing is a powerful approach for mapping genes with pleiotropic effects. However, the existing methods and the available software do not scale to analyses involving millions of SNPs and large datasets. This has limited the adoption of sequential testing for pleiotropy mapping at large scale. In this study, we present a sequential test and software that can be used to test pleiotropy in large systems of traits with bioban

SUBMITTER: Aguate FM 

PROVIDER: S-EPMC8633382 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature