Brain atrophy progression in Parkinson's disease is shaped by connectivity and local vulnerability.

ABSTRACT: Brain atrophy has been reported in the early stages of Parkinson's disease, but there have been few longitudinal studies. How intrinsic properties of the brain, such as anatomical connectivity, local cell-type distribution and gene expression combine to determine the pattern of disease progression also remains unknown. One hypothesis proposes that the disease stems from prion-like propagation of misfolded alpha-synuclein via the connectome that might cause varying degrees of tissue damage based on local properties. Here, we used MRI data from the Parkinson Progression Markers Initiative to map the progression of brain atrophy over 1, 2 and 4 years compared with baseline. We derived atrophy maps for four time points using deformation-based morphometry applied to T₁-weighted MRI f

SUBMITTER: Tremblay C 

PROVIDER: S-EPMC8633425 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature