Progression of Frailty in Survivors of Childhood Cancer: A St. Jude Lifetime Cohort Report.

ABSTRACT:

Background

Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence of frailty among survivors at 10 or more years after diagnosis, frailty prevalence 5 years later, and risk factors for becoming frail.

Methods

Frailty was measured at study entry and 5 years later. Logistic regression tested the associations of several factors with having frailty at 5 years for all participants and separately by sex and by study entry frailty status. Cox models evaluated the hazard of death associated with entry frailty considering covariates.

Results

Cancer survivors (range = 0-22 years at diagnosis, median = 7 years) were ages 18-45 years (median = 30 years) at study entry. Frailty pre

SUBMITTER: Delaney A 

PROVIDER: S-EPMC8633430 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature