A novel stroke lesion network mapping approach: improved accuracy yet still low deficit prediction.

ABSTRACT: Lesion network mapping estimates functional network abnormalities caused by a focal brain lesion. The method requires embedding the volume of the lesion into a normative functional connectome and using the average functional magnetic resonance imaging signal from that volume to compute the temporal correlation with all other brain locations. Lesion network mapping yields a map of potentially functionally disconnected regions. Although promising, this approach does not predict behavioural deficits well. We modified lesion network mapping by using the first principal component of the functional magnetic resonance imaging signal computed from the voxels within the lesioned area for temporal correlation. We measured potential improvements in connectivity strength, anatomical specificity of the

SUBMITTER: Pini L 

PROVIDER: S-EPMC8633453 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature