Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health Across the Life Span.

ABSTRACT: We developed and validated a synthetic cohort approach to examine numbers of cardiovascular risk factors (CRFs) and adverse clinical events, including incident cardiovascular disease and all-cause mortality, across the life span from ages 20 years to 90 years. The current analysis included 40,875 participants from 7 large, population-based longitudinal epidemiologic studies (1948-2016). On the basis of a joint multilevel imputation model, we multiply imputed each participant's life-span numbers of CRFs and events using available records. To validate the imputed values, we partially removed the observed data and then compared the imputed and observed values. The complete life-span synthetic data set reflected the original observed data trends well. In our validation sample, the distribution

SUBMITTER: Ning H 

PROVIDER: S-EPMC8633456 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature