The Significance of RHD Genotyping and Characteristic Analysis in Chinese RhD Variant Individuals.

ABSTRACT:

Background

RhD is the most important and complex blood group system because of its highly polymorphic and immunogenic nature. RhD variants can induce immune response by allogeneic transfusion, organ transplantation, and fetal immunity. The transfusion strategies are different for RhD variants formed by various alleles. Therefore, extensive investigation of the molecular mechanism underlying RhD variants is critical for preventing immune-related blood transfusion reactions and fetal immunity.

Methods

RhD variants were collected from donors and patients in Zhejiang Province, China. The phenotypes were classified using the serologic method. The full coding regions of RHD gene were analyzed using the PCR-SBT method. The multiplex ligation-dependent probe amplification (ML

SUBMITTER: Ying Y 

PROVIDER: S-EPMC8633534 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature