Investigation of hub gene associated with the infection of Staphylococcus aureus via weighted gene co-expression network analysis.

ABSTRACT:

Introduction

Staphylococcus aureus is a gram-positive bacterium that causes serious infection. With the increasing resistance of bacteria to current antibiotics, it is necessary to learn more about the molecular mechanism and cellular pathways involved in the Staphylococcus aureus infection.

Methods

We downloaded the GSE33341 dataset from the GEO database and applied the weighted gene co-expression network analysis (WGCNA), from which we obtained some critical modules. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were applied to illustrate the biological functions of genes in these modules. We constructed the protein-protein interaction (PPI) network by Cytoscape and selected five candidate hub genes. Five potential hub genes were validated in GSE301

SUBMITTER: Li JX 

PROVIDER: S-EPMC8633612 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature