Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers.

ABSTRACT: Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has emerged as a promising alternative therapy for the treatment of solid cancers. Since the first publication describing the anticancer effects of TTFields in 2004 there have been numerous follow-up studies by other groups, either to confirm the efficacy of TTFields or to study the primary mechanism of interaction. The overwhelming conclusion from these in vitro studies is that TTFields reduce the viability of aggressively replicating cell lines. However, there is still speculation as to the primary mechanism for this effect; moreover, observations both in vitro and in vivo of inhibited migration and metastases have been made, which may be unrelated to the originally proposed hypothesis of replication stres

SUBMITTER: Jones TH 

PROVIDER: S-EPMC8633677 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature