Polyunsaturated fatty acid-derived I_Ks channel activators shorten the QT interval ex-vivo and in-vivo.

ABSTRACT:

Aim

We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts.

Methods

The effect of one natural (docosahexaenoic acid [DHA]) and three modified (linoleoyl glycine [Lin-GLY], docosahexaenoyl glycine [DHA-GLY], N-arachidonoyl taurine [N-AT]) PUFAs on ventricular action potential duration (APD) and QT interval was studied in a E4031 drug-induced long QT2 model of ex-vivo guinea pig hearts. The effect of DHA-GLY on QT interval was also studied in in-vivo guinea pig hearts upon intravenous administration. The effect of modified PUFAs on I_Ks was studied using Xenopus laevis oocytes expressing human KCNQ1 and KCNE1.

Results

All tested PUFAs shortened ADP and QT interv

SUBMITTER: Skarsfeldt MA 

PROVIDER: S-EPMC8633721 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature