Genetic Diversity in Chimpanzee Transcriptomics Does Not Represent Wild Populations.

ABSTRACT: Chimpanzees (Pan troglodytes) are a genetically diverse species, consisting of four highly distinct subspecies. As humans' closest living relative, they have been a key model organism in the study of human evolution, and comparisons of human and chimpanzee transcriptomes have been widely used to characterize differences in gene expression levels that could underlie the phenotypic differences between the two species. However, the subspecies from which these transcriptomic data sets have been derived is not recorded in metadata available in the public NCBI Sequence Read Archive (SRA). Furthermore, labeling of RNA sequencing (RNA-seq) samples is for the most part inconsistent across studies, and the true number of individuals from whom transcriptomic data are available is difficult to ascerta

SUBMITTER: Shukla N 

PROVIDER: S-EPMC8633730 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature