Rapid Assay for Sick Children with Acute Lung infection Study (RASCALS): diagnostic cohort study protocol.

ABSTRACT:

Introduction

Lower respiratory tract infection (LRTI) is the most commonly treated infection in critically ill children. Pathogens are infrequently identified on routine respiratory culture, and this is a time-consuming process. A syndromic approach to rapid molecular testing that includes a wide range of bacterial and fungal targets has the potential to aid clinical decision making and reduce unnecessary broad spectrum antimicrobial prescribing. Here, we describe a single-centre prospective cohort study investigating the use of a 52-pathogen TaqMan array card (TAC) for LRTI in the paediatric intensive care unit (PICU).

Methods and analysis

Critically ill children with suspected LRTI will be enrolled to this 100 patient single-centre prospective observational study in a PICU

SUBMITTER: Clark JA 

PROVIDER: S-EPMC8634010 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature