The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease.

ABSTRACT: In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. We tested the hypothesis of a relationship between impairment of the dopaminergic system and changes in the iron metabolism. Based on imaging data of patients with prodromal and early clinical Parkinson's disease, we assessed the spatiotemporal ordering of such changes and relationships in the sensorimotor, associative and limbic territories of the nigrostriatal system. Patients with Parkinson's disease (disease duration < 4 years) or idiopathic REM sleep behaviour disorder (a prodromal form of Parkinson's disease) and healthy controls underwent longitudinal examination (baseline and 2-yea

SUBMITTER: Biondetti E 

PROVIDER: S-EPMC8634084 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature