The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study.

ABSTRACT:

Background and aims

To investigate the significance of 9 amino acids as risk factors for incident cardiovascular disease events in 9584 Finnish men.

Materials and methods

A total of 9584 men (age 57.4 ± 7.0 years, body mass index 27.2 ± 4.2 kg/m2) from the Metabolic Syndrome in Men study without cardiovascular disease and type 1 diabetes at baseline were included in this study. A total of 662 coronary artery disease (CAD) events, 394 ischemic stroke events, and 966 cardiovascular disease (CVD; CAD and stroke combined) events were recorded in a 12.3-year follow-up. Amino acids were measured using nuclear magnetic resonance platform.

Results

In Cox regression analysis, phenylalanine and tyrosine were significantly associated with increased risk of CAD and CVD events, an

SUBMITTER: Jauhiainen R 

PROVIDER: S-EPMC8634085 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature