Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.

ABSTRACT:

Importance

It is unclear whether administration of calcium has a beneficial effect in patients with cardiac arrest.

Objective

To determine whether administration of calcium during out-of-hospital cardiac arrest improves return of spontaneous circulation in adults.

Design, setting, and participants

This double-blind, placebo-controlled randomized clinical trial included 397 adult patients with out-of-hospital cardiac arrest and was conducted in the Central Denmark Region between January 20, 2020, and April 15, 2021. The last 90-day follow-up was on July 15, 2021.

Interventions

The intervention consisted of up to 2 intravenous or intraosseous doses with 5 mmol of calcium chloride (n = 197) or saline (n = 200). The first dose was administered immediately after the

SUBMITTER: Vallentin MF 

PROVIDER: S-EPMC8634154 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature