Transcriptome-Wide Map of N⁶-Methyladenosine Methylome Profiling in Human Bladder Cancer.

ABSTRACT: N⁶-Methyladenosine (m⁶A) is the most widespread internal RNA modification in several species. In spite of latest advances in researching the biological roles of m⁶A, its function in the development and progression of bladder cancer remains unclear. In this study, we used MeRIPty -55-seq and RNA-seq methods to obtain a comprehensive transcriptome-wide m⁶A profiling and gene expression pattern in bladder cancer and paired normal adjacent tissues. Our findings showed that there were 2,331 hypomethylated and 3,819 hypermethylated mRNAs, 32 hypomethylated and 105 hypermethylated lncRNAs, and 15 hypomethylated and 238 hypermethylated circRNAs in bladder cancer tissues compared to adjacent normal tissues. Furthermore, m⁶A is most often harbor

SUBMITTER: Li A 

PROVIDER: S-EPMC8634328 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature