Circulating Ceramides and Sphingomyelins and Risk of Mortality: The Cardiovascular Health Study.

ABSTRACT:

Background

Recent studies suggest that associations of ceramides (Cer) and sphingomyelins (SM) with health outcomes differ according to the fatty acid acylated to the sphingoid backbone. The purpose of this study was to assess associations of Cer and SM species with mortality.

Methods

The study population included participants from the Cardiovascular Health Study (CHS), a community-based cohort of adults aged ≥65 years who were followed from 1992-2015 (n = 4612). Associations of plasma Cer and SM species carrying long-chain (i.e., 16:0) and very-long-chain (i.e., 20:0, 22:0, 24:0) saturated fatty acids with mortality were assessed using Cox proportional hazards models.

Results

During a median follow-up of 10.2 years, 4099 deaths occurred. High concentrations of Cer an

SUBMITTER: Fretts AM 

PROVIDER: S-EPMC8634404 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature